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Calsyntenin-1

WebAug 1, 2016 · Calsyntenin-1 has previously been shown to mediate transport of endosomes along microtubules in neurons, through interactions with kinesin light chain-1. Here we demonstrate for the first time, we believe, a similar role for calsyntenin-1 in Huh7 cells, mediating intracellular transport of endosomes. In HCV-infected cells we show that ... WebJan 1, 2001 · We termed this protein calsyntenin-1, because it binds synaptic Ca 2+ with its cytoplasmic domain. By binding Ca 2+, calsyntenin-1 may modulate Ca 2+-mediated …

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WebJun 27, 2012 · In accordance with the identification of calsyntenin-1/APP vesicles as a distinctive carrier for anterograde axonal transport of APP we found that calsyntenin-1 and APP exit the TGN together in a vesicle with early-endosomal characteristics (Ludwig et al., 2009) and that all calsyntenin-1 vesicles are transported anterogradely along axons ... WebSep 9, 2024 · CLSTN1:calsyntenin 1 [Gene - OMIM - HGNC] Variant type: single nucleotide variant Cytogenetic location: 1p36.22 Genomic location: ... 1: not provided: not provided: 1: not provided: not provided: not provided: Last Updated: Feb 13, 2024. Follow NCBI. Connect with NLM. National Library of Medicine ... rock baby boy https://mommykazam.com

Cognitive Deficits in Calsyntenin-2-deficient Mice Associated with ...

WebApr 1, 2008 · The cytoplasmic region of mammalian calsyntenin-1 binds Ca 2+, and it was proposed that calsyntenins may be involved in proteolysis-dependent modulation of synaptic functions through its Ca 2+-binding capacity (13, 26). Based on this idea, the cytoplasmic region of CASY-1 may be essential for learning in C. elegans. WebJul 9, 2014 · Here we identify a kinesin adaptor, Calsyntenin-1 (Clstn-1), as an essential regulator of axon branching and neuronal compartmentalization in vivo. We use morpholino knockdown and a Clstn-1 mutant to show that Clstn-1 is required for formation of peripheral but not central sensory axons, and for peripheral axon branching in zebrafish. WebApr 1, 2011 · Calsyntenin-1 was detected through the EGFP tag and KLC1 using the anti-FLAG antibody; images shown are confocal sections. (A) Calsyntenin-1 is highly co-localised with wild-type and both mutant KLC1s in perinuclear regions. In addition calsyntenin-1 and FLAG–KLC1ser460ala co-localise in plasma membrane projections; … ostiones png

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Calsyntenin-1

Innervation of thermogenic adipose tissue via a calsyntenin

WebCatalog Number ELH-CLSTN1-1; Quantity 1 x 96-Well Strip Microplate Kit; Applications Sandwich-based ELISA Kits; Detection Colorimetric; Detection Target Calsyntenin-1; NCBI Full Gene Name calsyntenin 1; NCBI Gene Aliases CDHR12, alcalpha2, alcalpha1, PIK3CD, ALC-ALPHA, CSTN1, XB31alpha, CST-1; Reactivity Human WebDec 1, 2024 · A recent study has shown that LDIR regulates the expression of mir-193b-3p, which targets Calsyntenin 1 (CLSTN1) and serine hydroxymethyltransferase 2 (SHMT2) …

Calsyntenin-1

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WebCalsyntenin-1(CLSTN1) plays a critical role in the nervous system, but its relevance in cardiovascular diseases is unknown. We investigated the significance of CLSTN1 in doxorubicin-induced DCM. Methods: CLSTN1 expression in doxorubicin-induced DCM rats and H9c2 cells was determined using western blotting. To further explore the functions of ... WebCalsyntenin-1, also known as CSTN1, PIK3CD, Alzheimer-related cadherin-like protein, non-classical cadherin XB31alpha, KIAA0911, ALC-ALPHA, alcalpha1, alcalpha2 or FLJ32258, is a 981 amino acid single-pass type I membrane protein that localizes to the membrane of endoplasmic reticulum, Golgi apparatus, cell projections and postsynaptic …

WebCalsyntenin-1 is a neuronally enriched type-1 membrane-spanning protein that binds directly to KLCs via its intracellular C-terminal domain (13–16). As such, calsyntenin-1 acts as a ligand to mediate transport of a subset of vesicles through axons on kinesin-1 motors. A proportion of APP and calsyntenin-1 co-localize in cells and tissues, and ... WebSep 22, 2024 · This gene is a member of the calsyntenin family, a subset of the cadherin superfamily. The encoded transmembrane protein, also known as alcadein-alpha, is …

WebAug 15, 2012 · Here we characterized the function of calsyntenin-1 in neuronal APP transport using selective immunoisolation of intracellular trafficking organelles, … WebNov 9, 2024 · Calsyntenin-1 (CLSTN1), a type I transmembrane protein, is a member of the cadherin superfamily of cell-adhesion molecules. Although the brain displays the highest levels of expression, CLSTN1 can also be …

WebOct 2, 2013 · However, calsyntenin-1 and calsyntenin-2 lack synaptogenic activity, and we could detect no interaction with neurexin (Figures 4 and S1). Calsyntenin-1 was found to act as an organelle adaptor that links kinesin-1 light chain to transport vesicles (Araki et al., 2007, Konecna et al., 2006, Vagnoni et al., 2011). No role for calsyntenin-3 has ...

WebRayBio® Human Calsyntenin-1 (Alcadein-alpha) ELISA Kit. 4 - 7 week lead time. This ELISA uses an antibody pair and standard that have been validated for multiplex array … ostion frescoWeb胎牛血清（杂交瘤细胞专用） sp2/0 小鼠骨髓瘤细胞. 佐剂乳化器 rock baby babyWebDec 31, 2024 · Calsyntenin-1 directly correlated with global pathological tau burden in FTLD (r 2 =.22; p=0.005) and in “pure FTLD” (r 2 =.17; p=0.02). Conclusion Low CSF levels of the post-synaptic modulator, Calsyntenin-1, is specific to FTLD, particularly in cases with little or no tau pathology and could aid the early diagnosis of FTD and the ... ostion placerWebMay 1, 2024 · Adipose-specific ablation of lysine-specific demethylase 1 (Lsd1, also known as Kdm1a) has previously been found to cause severe BAT dysfunction 13.Expression of calsyntenin 3 (Clstn3) is strongly ... ostioneria michoacanWebSep 22, 2024 · This gene is a member of the calsyntenin family, a subset of the cadherin superfamily. The encoded transmembrane protein, also known as alcadein-alpha, is … ostirich xt tabWebJun 25, 2014 · Calsyntenin-1 is a transmembrane cargo-docking protein important for kinesin-1-mediated fast transport of membrane-bound organelles that exhibits peak expression levels at postnatal day 7. However, its neuronal function during postnatal development remains unknown. We generated a knock-out mouse to characterize … ostioneria arandas 10th anniversaryWebCalsyntenin-1 is a neuronally enriched type-1 membrane-spanning protein that binds directly to KLCs via its intracellular C-terminal domain (13–16). As such, calsyntenin-1 … rock baby back and forth