Myc and atf4
Web7 feb. 2024 · Citation 45 Recently, MYC signaling was demonstrated to be regulated by AAMDC, an oncogene that controls the translation of MYC and ATF4. Citation 16 This finding was verified in our study, as evidenced by solanine-induced AAMDC downregulation resulting in the deactivation of the MYC-ATF4-Sesn2 pathway in nude mice and gastric … WebRecently, we showed that 2-Cl-Phen attenuated not only GRP78 and ATF4 expression but also c-Myc, a well-known oncogenic factor, in HT-29 cells under a serum-and glucose …
Myc and atf4
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Web5 jan. 2024 · While not as widely studied in the context of amino acid restriction as ATF4, c-MYC has emerged as an important regulator of glucose and glutamine metabolism in cancer cells. c-MYC supports non-oxidative glucose metabolism through transcriptional upregulation of glucose transporter GLUT1, multiple glycolytic enzymes, and the lactate … Web21 mei 2024 · Additionally, Erk can phosphorylate c-Myc, leading to its stabilization and activation. Mithramycin, ... However, whether they can modify transcription factors such as ATF4 or c-Myc that have been implicated in pro-death responses to neuronal ferroptosis in neurons is not established. Iron in Ferroptosis: ...
Web21 aug. 2014 · Mechanistically, we identified ATF4 as a novel regulator which coordinates with N-Myc to directly activate ASCT2 expression. Of note, ASCT2 expression, which … Web22 aug. 2024 · Further studies revealed that MYC had a transcriptional effect on MTHFD2 and was also regulated by ATF4. PCR, and western blotting experiments with ATF4 …
WebATF4 suppresses mTORC1-dependent signalling and inhibition of mTORC1 reduces cell death of ATF4-deficient cells following MYC activation a, ATF4 and MYC ChIP followed … Web13 nov. 2012 · ATF4 then activates PUMA and other genes (e.g., NOXA and TRB3) involved in the execution of cell death, sensitizing tumor cells to Myc-mediated apoptosis. Like …
Web26 dec. 2024 · Elevated EAAs, in turn, stimulate Myc mRNA translation, in part through attenuation of the GCN2-eIF2α-ATF4 amino acid stress response pathway, leading to …
Web1 jul. 2024 · Subsequently, ATF4 co-occupies promoter regions of over 30 MYC target genes, primarily those regulating amino acid and protein synthesis, including 4E-BP1, a negative regulator of translation. 4E-BP1 is essential to balance protein synthesis, relieving MYC-induced proteotoxic stress. 4E-BP1 activity is negatively regulated by mTORC1 … dnd slime 5eWeb12 okt. 2015 · ATF4 and N-Myc coordinate glutamine metabolism in MYCN-amplified neuroblastoma cells through ASCT2 activation. J Pathol 2015; 235 : 90–100. Article CAS … dnd slime race 5eWeb1 aug. 2024 · In this issue of Cancer Research, Xia and colleagues show that MYC-induced metabolic reprograming results in dependency on the serine-glycine-one-carbon (SGOC) … dnd snake raceWeb8 feb. 2024 · In turn, elevated c-MYC supports ATF4 translational induction by enhancing the expression of the amino acid transporter SLC7A5, increasing the uptake of essential amino acids, and the subsequent maintenance of mTORC1 activity in asparagine-restricted melanoma cells. dnd slug raceWeb8 okt. 2024 · ATF4 is a crucial transcription factor in the integrated stress response, a major adaptive signaling pathway activated by tumor microenvironment and therapeutic … dnd snacksWebATF4 couples MYC-dependent translational activity to bioenergetic demands during tumour progression. The c-Myc oncogene drives malignant progression and induces robust … dnd snakeWeb1 jan. 2015 · Mechanistically, we identified ATF4 as a novel regulator which coordinates with N‐Myc to directly activate ASCT2 expression. Of note, ASCT2 expression, which … dnd slime races