2024 Regulation of body fat in c. elegans

Regulation of body fat in c. elegans

Author: cymz

August undefined, 2024

WebThe complete wiring diagram of the C. elegans nervous system has been exploited to understand how the sensory nervous system regulates body fat and how food perception is coupled with the production of energy via fat metabolism. As a model organism, C. …

Genome-wide RNAi analysis of Caenorhabditis elegans fat regulatory genes

WebJul 1, 2013 · The Caenorhabditis elegans (C. elegans) model organism is practical for research on many human diseases. • We report that a subgroup of legumes is able to reduce body fat while increasing lifespan in the wild type C. elegans (N2). • Dietary legumes as a nutritious food source also help to reduce the global obesity epidemic and diabetes. WebOct 11, 2024 · In previous work, we showed that SMA-3/Smad activity in the hypodermis (epidermis) regulates fat accumulation in the C. elegans intestine, and that SMA-3/Smad regulation of fat stores depends on the DAF-2 Insulin Receptor (InsR) and is not associated with altered pharyngeal pumping that would modulate feeding rate . graise lawn service

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WebApr 16, 2024 · Researchers discovered that, in the lab worm C. elegans, certain scents dynamically regulate fat mobilization by interacting with specific olfactory neurons through specific receptors. WebThe quantification of fats accumulated in the C. elegans body may be conducted via biochemical assays, measuring fat uptake and fat oxidation, and via other methods appropriate for most model ... WebJan 5, 2024 · Section snippets Low-dose cadmium promoted fat accumulation in C. elegans. To explore the effect of low-dose cadmium exposure on fat accumulation in C. elegans, we cultivated nematodes in media containing CdCl 2 from the larval stage (L4) and monitored the fat storage at different timepoints in the adult stage. Using the transgenic … china omicron cases today

Caenorhabditis elegans as a model for obesity research

Function and Regulation of Lipid Biology in Caenorhabditis …

WebFor example, the expression of a single metastable (temperature-sensitive) protein such as metastable myosin in the body wall muscle cells of C. elegans leads to a compensatory up-regulation of muscle-autonomous expression of hsp90 and a transcriptional feedback that normalizes hsp90 expression across the organism (van Oosten-Hawle et al. 2013). WebIn C. elegans, loss of the peptide NT PEPT-1 results in higher uptake of free fatty acids and accumulation of body fat due to an increase in [H +] on the mucosal luminal surface ; conversely, loss of the sodium-proton exchanger NHX-2 leads to lower uptake of free fatty acids and reductions in body fat due to a decrease in [H +] on the mucosal ... china omicron covid casesWeb2 Adult Anatomy 2.1 Body Shape. Similar to other nematodes, C. elegans has an unsegmented, cylindrical body shape that is tapered at the ends (IntroFIG 1; IntroMOVIE 1).This is the typical nematode body plan, with an outer tube and an inner tube separated by the pseudocoelomic space ().The outer tube (body wall) consists of cuticle, hypodermis, … china on1

"Web3.4. BMS Altered the Fat Accumulation of Glucose-Treated C. elegans. C. elegans has been widely used as an in vivo model for exploring the genetic regulation of fat storage, due to the fact that many aspects of fat synthesis and breakdown pathways characterized in humans are conserved in this easy-handling organism [].The intestine in C. elegans consists of 20 … " - Regulation of body fat in c. elegans

Regulation of body fat in c. elegans

‘Inside Out’– a dialogue between mitochondria and bacteria

WebC. elegans fat accumulation is regulated by a complex molecular network, including hundreds of genes with functions in food sensation, neuroendocrine signaling, and … WebApr 13, 2024 · c, d Triglyceride content (c, n = 8–11) and Nile Red staining of the fat bodies (d) collected from flies of the indicated genotypes at different treatment temperatures (12 h at 30 °C; 20 °C ...

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WebC. elegans has more recently been exploited to study the interplay of environment and genetics on lipid storage pathways. As an experimental platform, C. elegans is amenable … WebMitochondria play crucial roles in regulating metabolism and longevity. A body of recent evidences reveals that the ... of bacterial diet on fat storage in C. elegans. PLoS ONE 4, e7545. 143 ...

WebIn C. elegans, the dynamic expression of neuropeptides has been described to control several fundamental behavioral programs, e.g., mating [61], feeding [38], sleep [62], and others [49]. WebNov 5, 2013 · In this report we describe a C. elegans neuroendocrine signaling pathway that originates in the nervous system, and operates via body cavity neurons to regulate body fat in C. elegans. We describe the neural circuit for 5-HT-mediated fat loss and show that 5-HT signaling requires Oct synthesis via tbh-1 in the RIC neurons, and that Oct administration …

WebJul 3, 2024 · To date, evidence from C. elegans has shown that the central nervous system plays a profound role in regulating the storage of body fat and energy expenditure, … WebOct 20, 2014 · Abstract and Figures. Over the past decade, studies conducted in Caenorhabditis elegans have helped to uncover the ancient and complex origins of body …

WebSupporting: 3, Mentioning: 68 - Studies conducted in C. elegans over the last decade highlight the ancient and complex origins of body fat regulation. In this critical review, I …

WebApr 4, 2013 · C. elegans: a genetic model to study metabolic regulation. We are using C. elegans to study the role of KLF in the control of factors that play important role in mammalian metabolic regulation. ... Caloric restriction, body fat and ageing in experimental models. Obes Rev. 2004, 5: 13-19. 10.1111/j.1467-789X.2004.00115.x. graiseley court wolverhamptonWebThe C. elegans insulin/IGF-1 (insulin-like growth factor 1) signaling mutant daf-2 recapitulates the dauer metabolic signature—a shift towards lipid and carbohydrate accumulation—which may be linked to its longevity and stress resistance phenotypes. Trehalose, a disaccharide of glucose, is highly upregulated in daf‑2 mutants and it has … graiphics bundle dealWebOur data implied that loss of function of CEBP-2 displayed a low-fat phenotype in C. elegans owing to increased expression of ech-1.1 and decreased expression of fat-5. Our findings indicated that cebp-2 controls total body fat content by governing fatty acid mitochondrial β-oxidation and desaturation in C. elegans. china olympic swimming facilitiesWebMar 1, 2009 · This critical review introduces the major functional approaches used to study energy balance and body fat, the lipid composition of C. elegans, the regulation of cellular fat metabolism and its transcriptional control, and the major regulatory mechanisms that couple food perception in the nervous system with the production of energy via fat … graiseley hubWebOver the past decade, studies conducted in Caenorhabditis elegans have helped to uncover the ancient and complex origins of body fat regulation. This review highlights the … china oncologyWebMay 10, 2011 · C. elegans regulation of feeding. ... which cause accumulation of body fat. 62. Obesity therapeutics. C. elegans exposed to compounds that can potentially increase … china onceWebOver the past decade, studies conducted in Caenorhabditis elegans have helped to uncover the ancient and complex origins of body fat regulation. This review highlights the … china on a global map